Simin Namvar Aghdash; Roya Mirzaee
Volume 22, Issue 5 , November and December 2015, , Pages 902-908
Abstract
Background & Objectives: Epilepsy is one of the most common neurological disorders in the world. It affects, at least, on 0.5–2% of people worldwide. It causes serious physical, psychological, social, and economic consequences. Despite a variety of current procedures for treatment of epilepsy, ...
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Background & Objectives: Epilepsy is one of the most common neurological disorders in the world. It affects, at least, on 0.5–2% of people worldwide. It causes serious physical, psychological, social, and economic consequences. Despite a variety of current procedures for treatment of epilepsy, research for discovering new drugs has been continued. Although medicinal plants have been used in traditional medicine for treatment of epilepsy, only a few of the medicinal plants have been examined scientifically. The aim of this study was to study the effect of Thymus vulgaris extract in the treatment of seizure.
Materials & Methods: In this study, 48 mice have been chosen randomly and divided into 6 groups, including control group, sham group that received distilled water, and 4 experimental groups that received aqueous extract of Thymus vulgaris in doses of 100, 200, 400 and 800 mg/kg for 4 weeks. 30 minutes after gavage with different doses of the extract or distilled water, pentylenetetrazol was injected to experimental and sham groups. Animals immediately transferred to a special cage and the seizure behaviors and parameters were recorded by a camera. Then the different phases of seizure were evaluated.
Results: Data analysis indicated that the aqueous extract of Thymus vulgaris had a significant effect on PTZ-induced seizure. The results showed that therapy by this extract increases latency time for onset of seizure and prevents progress of seizure phases.
Conclusion: The attained results showed that Thymus vulgaris extract has anticonvulsant effect on PTZ-induced seizure. Thus, it may be used in seizure treatment.